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The most studied modifications in the context of macrophage polarization are histone methylation and acetylation, which are initiated by histone methyltransferases (HMTs) and demethylases (HDMs), acetyltransferases (HATs) and deacetylases (HDACs)
Ethical approval This study was approved by the Ethics Committee of the Department of Animal Biology, Faculty of Science (025/13/304FSa) and by the Directorate of in vivo Animal Research Reports, in accordance with ARRIVE 2.0 guidelines
NAC suggests being one possibility connecting earlier hypothesised concepts of depression, and many of its effects could be related to this compounds antidepressant effects
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